Solution-What other factors may influence the reliability

Question #1: GPRCs and Cancer

GPCRs and Cancer: The G-protein coupled receptor (GPCR) family of proteins boasts over 800 members, and more than 2% of the human genome codes for GPCRs. GPCRs are upstream of many of the regulatory signaling pathways discussed in this unit. The review by Dorsam and Gutkind details the role of GPCRs in cancer. Table 1 includes a comprehensive list of GPCRs in various types of cancers.
Choose one specific receptor to discuss: include the specific role of this receptor in the target cancer and the effects on the cell resulting from aberrant expression or dysregulation of the receptor (and known mechanisms by which this occurs). Integrate crosstalk or interaction with other pathways discussed in Unit 3.

Don't use plagiarized sources. Get Your Custom Essay on
Solution-What other factors may influence the reliability
Just from $13/Page
Order Essay

Question #2: Ras in the Clinic

Ras in the Clinic: Ras mutation status (particularly mutations in KRAS and BRAF) has been used as a predictor of prognosis in colorectal cancer. Specifically, Ras mutation status has been used to predict resistance to anti-EGFR inhibitors in the clinic (patients who harbor wild type versions of these genes tend to fair better than patients who harbor mutations). However, these predictions have been controversial. As the field of cancer moves toward more personalized therapies, the identification of successful biomarkers and predictors is pivotal.

What is your opinion on the predictive value of these markers? What other factors may influence the reliability of these data (integrate knowledge of the Ras signaling pathway and/or the interaction of effector proteins on cancer cell behavior).

Question #3: K-ras and Inflammation

Cancer Risk Factors – K-ras and Inflammatory Stimuli: Studies suggest that the presence of oncogenic Ras is not sufficient to drive tumorigenesis. Instead, the activity of Ras needs to be amplified and sustained to induce pathological consequences. The study below offers a novel perspective in the role of inflammatory stimuli on tumor development in the context of oncogenic Ras. The textbook does not present the entire picture in regards to Ras activation – remember that even if inactivation by GAPs is reduced by a mutation, mutant Ras still needs GTP binding to occur to be activated (and this signal needs to be sustained in order to perpetuate downstream target effects). Is the presence of oncogenic Ras necessary for transient inflammatory stimulation to induce chronic pathologies (such as cancer) or is chronic inflammation essential for oncogenic Ras to induce tumorigenesis?

In your own words, where does Ras fit into the larger picture of the tissue microenvironment in the context of inflammation?

Place your order
(550 words)

Approximate price: $22

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
$26
The price is based on these factors:
Academic level
Number of pages
Urgency
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.